Issue 46, 2014

Shape transformation following reduction-sensitive PEG cleavage of polymer/DNA nanoparticles

Abstract

PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surface charges, correlating with improved transfection efficiency.

Graphical abstract: Shape transformation following reduction-sensitive PEG cleavage of polymer/DNA nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
16 Qas 2014
Accepted
11 Leq 2014
First published
15 Leq 2014

J. Mater. Chem. B, 2014,2, 8106-8109

Shape transformation following reduction-sensitive PEG cleavage of polymer/DNA nanoparticles

J. Williford, Y. Ren, K. Huang, D. Pan and H. Mao, J. Mater. Chem. B, 2014, 2, 8106 DOI: 10.1039/C4TB00967C

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