Issue 17, 2025
From the journal:

Nanoscale

Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery†

Shiwei Fu,‡a   Miao Zhang,‡de   Nicholas Calzadilla,‡a   Bowen Zhao,a   Xiao Zhang, ORCID logo a   Bowei Yang,de   Victoria A. A. McKenzie,a   Ajay Zheng, ORCID logo a   Qianqian Ni*de  and  Fuwu Zhang ORCID logo *abc  

* Corresponding authors

a Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida, USA
E-mail: fxz174@miami.edu

b The Dr John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami, Miami, FL 33136, USA

c Sylvester Comprehensive Cancer Centre, University of Miami Miller School of Medicine, Miami, Florida 33136, USA

d Nanomedicine Translational Research Program, NUS Centre for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
E-mail: qqian.ni@nus.edu.sg

e Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore

Abstract

Smart polymer prodrugs, created via responsive prodrug-initiated controlled polymerization of lactide, demonstrated extremely high drug loading, tuneable stimuli-triggered drug release, and significant tumor growth inhibition and improved survival with minimal toxicity. This adaptable strategy can precisely tailor drugs’ physicochemical properties for optimal therapeutic efficacy, demonstrating great promise for cancer treatment.

Graphical abstract: Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery

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Article information

DOI
https://doi.org/10.1039/D5NR00780A
Article type
Communication
Submitted
21 Nah 2025
Accepted
03 Agd 2025
First published
04 Agd 2025
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2025,17, 10595-10599

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Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery

S. Fu, M. Zhang, N. Calzadilla, B. Zhao, X. Zhang, B. Yang, V. A. A. McKenzie, A. Zheng, Q. Ni and F. Zhang, Nanoscale, 2025, 17, 10595 DOI: 10.1039/D5NR00780A

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