Probing Polarity Structure-Function Relationships in Amine-Water Mixtures

Abstract

This study investigates the relationships between chemical structure, polarity, and miscibility in solvent-water systems to elucidate the mechanisms underlying the thermoresponsive hydrophilicity of amines. By integrating complementary analyses of Kamlet-Taft parameters and relative permittivity, we elucidate that hydrogen bonding and nanoscale ordering, i.e., molecular-level and mean-field, respectively, underlie amine-water interactions, which, in turn, influence the thermomorphic hydrophilicity function.