Issue 11, 2024

Protein–polymer bioconjugation, immobilization, and encapsulation: a comparative review towards applicability, functionality, activity, and stability

Abstract

Polymer-based biomaterials have received a lot of attention due to their biomedical, agricultural, and industrial potential. Soluble protein–polymer bioconjugates, immobilized proteins, and encapsulated proteins have been shown to tune enzymatic activity, improved pharmacokinetic ability, increased chemical and thermal stability, stimuli responsiveness, and introduced protein recovery. Controlled polymerization techniques, increased protein–polymer attachment techniques, improved polymer surface grafting techniques, controlled polymersome self-assembly, and sophisticated characterization methods have been utilized for the development of well-defined polymer-based biomaterials. In this review we aim to provide a brief account of the field, compare these methods for engineering biomaterials, provide future directions for the field, and highlight impacts of these forms of bioconjugation.

Graphical abstract: Protein–polymer bioconjugation, immobilization, and encapsulation: a comparative review towards applicability, functionality, activity, and stability

Article information

Article type
Review Article
Submitted
16 Xim 2023
Accepted
23 Agd 2024
First published
29 Agd 2024

Biomater. Sci., 2024,12, 2841-2864

Protein–polymer bioconjugation, immobilization, and encapsulation: a comparative review towards applicability, functionality, activity, and stability

B. Çalbaş, A. N. Keobounnam, C. Korban, A. J. Doratan, T. Jean, A. Y. Sharma and T. A. Wright, Biomater. Sci., 2024, 12, 2841 DOI: 10.1039/D3BM01861J

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