Issue 15, 2023

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Abstract

Non-viral polymeric vectors with good biocompatibility have been recently explored as delivery systems for clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) nucleases. In this review, based on current limitations and critical barriers, we summarize the advantages of stimulus-responsive polymeric delivery vectors (i.e., pH, redox, or enzymes) towards controllable CRISPR/Cas9 genome editing system delivery as well as the advances in using stimulus-responsive CRISPR/Cas9 polymeric carriers towards cancer treatment. Last but not least, the key challenges and promising development strategies of stimulus-responsive polymeric vector designs for CRISPR/Cas9 systems will also be discussed.

Graphical abstract: Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Article information

Article type
Review Article
Submitted
29 Cig 2023
Accepted
17 Cax 2023
First published
19 Cax 2023

Biomater. Sci., 2023,11, 5078-5094

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

P. Ma, Q. Wang, X. Luo, L. Mao, Z. Wang, E. Ye, X. J. Loh, Z. Li and Y. Wu, Biomater. Sci., 2023, 11, 5078 DOI: 10.1039/D3BM00529A

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