Issue 27, 2022

Superoxide dismutase-embedded metal–organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease

Abstract

Inflammatory bowel disease (IBD) is characterized by chronic and spontaneous inflammation in the gastrointestinal tract, and has been associated with an improved level of reactive oxygen species (ROS). Herein, superoxide dismutase (SOD) was encapsulated into zeolitic imidazolate framework-zni (ZIF-zni) to construct a nanocomposite termed SOD@ZIF-zni through biomimetic mineralization, which was then used as a formulation for the IBD treatment. The SOD@ZIF-zni composite could efficiently suppress the level of ROS and pro-inflammatory cytokines, using the colorectal cancer cell line SW480 as a model. Oral administration of the SOD@ZIF-zni composite could relieve the oxidative stress and inhibit the release of pro-inflammatory cytokines in the inflamed colonic tissues, leading to the alleviation of colitis in dextran sulfate sodium-induced colitis mice. Overall, the favorable therapeutic efficacy and biocompatibility of SOD@ZIF-zni gave it potential to be used as a safe and effective formulation for IBD treatment in the future.

Graphical abstract: Superoxide dismutase-embedded metal–organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease

Supplementary files

Article information

Article type
Paper
Submitted
25 Agd 2022
Accepted
19 Qas 2022
First published
20 Qas 2022

J. Mater. Chem. B, 2022,10, 5174-5181

Superoxide dismutase-embedded metal–organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease

S. Bai, X. Shao, Y. Tao, S. Wang, H. Han and Q. Li, J. Mater. Chem. B, 2022, 10, 5174 DOI: 10.1039/D2TB00896C

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