Issue 20, 2022

Versatile metal–organic frameworks as a catalyst and an indicator of nitric oxide

Abstract

The imaging of nitric oxide (NO) and its donors is crucial to explore NO-related physiological and pathological processes. In this work, we demonstrate the use of Cu-based metal–organic frameworks (Cu-MOFs) as nanoprobes for NO detection and as a catalyst for the generation of NO from the biologically occurring substrate, S-nitrosothiols (RSNOs). The paramagnetic Cu2+ in the MOFs could quench the luminescence of triphenylamine; Cu-MOFs only exhibited weak emission at 450 nm. Upon the addition of NO, the paramagnetic Cu2+ was reduced to diamagnetic Cu+, and thus the luminescence was recovered directly. Cu-MOFs exhibited high selectivity for other species in the reaction system, including NO2, H2O2, AA, NO3 and 1O2. More significantly, the Cu+ can react with s-nitrosoglutathione (GSNO), s-nitrosocysteine (CysNO), and s-nitrosocysteamine (CysamNO) to generate NO and then oxidize to Cu2+-MOFs with quenched luminescence, respectively, and thus the catalysis is inhibited, noted as a self-controlled process. The Cu-MOFs catalyst was confirmed by powder X-ray diffraction to remain structurally intact in aqueous environments. The Cu-MOFs have been successfully employed in the biological imaging of NO in living cells. The bifunctional MOFs could offer a novel platform for the real-time monitoring of NO species, provide potential for exploiting NO in cancer therapy and improve the methodologies to elucidate the NO-related biological processes.

Graphical abstract: Versatile metal–organic frameworks as a catalyst and an indicator of nitric oxide

Supplementary files

Article information

Article type
Paper
Submitted
05 Cig 2022
Accepted
13 Agd 2022
First published
13 Agd 2022

J. Mater. Chem. B, 2022,10, 3817-3823

Versatile metal–organic frameworks as a catalyst and an indicator of nitric oxide

P. Ling, X. Gao, X. Sun, P. Yang and F. Gao, J. Mater. Chem. B, 2022, 10, 3817 DOI: 10.1039/D2TB00480A

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