Issue 3, 2022

Cu-mediated vs. Cu-free selective borylation of aryl alkyl sulfones

Abstract

A Cu-catalysed borylation of aryl alkyl sulfones was developed for the high yield synthesis of versatile arylboronic esters using a readily prepared NHC–Cu catalyst. In addition, the selective cleavage of either alkyl(C)–sulfonyl or aryl(C)–sulfonyl bonds of a cyclic sulfone via Cu-free or Cu-mediated processes generates the corresponding sulfinate salts, which can be further derivatised to provide sulfonyl-containing boronate esters, such as sulfones and sulfonyl fluorides.

Graphical abstract: Cu-mediated vs. Cu-free selective borylation of aryl alkyl sulfones

Supplementary files

Article information

Article type
Communication
Submitted
31 Dit 2021
Accepted
03 Kax 2021
First published
03 Kax 2021

Chem. Commun., 2022,58, 395-398

Cu-mediated vs. Cu-free selective borylation of aryl alkyl sulfones

M. Huang, M. Tang, J. Hu, S. A. Westcott, U. Radius and T. B. Marder, Chem. Commun., 2022, 58, 395 DOI: 10.1039/D1CC06144E

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