Issue 33, 2021

Functional biomedical materials derived from proteins in the acquired salivary pellicle

Abstract

In the oral environment, the acquired salivary pellicle (ASP) on the tooth surface comprises proteins, glycoproteins, carbohydrates, and lipids. The ASP can specifically and rapidly adsorb on the enamel surface to provide effective lubrication, protection, hydration, and remineralisation, as well as be recognised by various bacteria to form a microbial biofilm (plaque). The involved proteins, particularly various phosphoproteins such as statherins, histatins, and proline-rich proteins, are vital to their specific functions. This review first describes the relationship between the biological functions of these proteins and their structures. Subsequently, recent advances in functional biomedical materials derived from these proteins are reviewed in terms of dental/bone therapeutic materials, antibacterial materials, tissue engineering materials, and coatings for medical devices. Finally, perspectives and challenges regarding the rational design and biomedical applications of ASP-derived materials are discussed.

Graphical abstract: Functional biomedical materials derived from proteins in the acquired salivary pellicle

Article information

Article type
Review Article
Submitted
19 Cax 2021
Accepted
01 Qad 2021
First published
01 Qad 2021

J. Mater. Chem. B, 2021,9, 6507-6520

Functional biomedical materials derived from proteins in the acquired salivary pellicle

F. Zhang, Z. Cheng, C. Ding and J. Li, J. Mater. Chem. B, 2021, 9, 6507 DOI: 10.1039/D1TB01121A

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