A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles

Yusuke Kobayashi; Sota Masakado; Takuya Murai; Shohei Hamada; Takumi Furuta; Yoshiji Takemoto

doi:10.1039/D1OB00947H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles†

Yusuke Kobayashi,

*^a Sota Masakado,^b Takuya Murai,^a Shohei Hamada,

^a Takumi Furuta

^a and Yoshiji Takemoto

*^b

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan
E-mail: ykobayashi@mb.kyoto-phu.ac.jp

^b Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: takemoto@pharm.kyoto-u.ac.jp

Abstract

ortho-Nitro-substituted N-trifluoroacetyl imino-λ³-iodane is a bench-stable trifluoroacetyl nitrene precursor, in which intra- and intermolecular halogen bonding (XB) plays an important role. Potential synthetic applications of this novel precursor were explored.

This article is part of the themed collection: Halogen bonding in organic synthesis and catalysis

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D1OB00947H
Article type: Communication
Submitted: 14 Cax 2021
Accepted: 07 Qad 2021
First published: 07 Qad 2021

Download Citation

Org. Biomol. Chem., 2021,19, 6628-6632

Permissions

Request permissions

A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles

Y. Kobayashi, S. Masakado, T. Murai, S. Hamada, T. Furuta and Y. Takemoto, Org. Biomol. Chem., 2021, 19, 6628 DOI: 10.1039/D1OB00947H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry

A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles

Social activity

Search articles by author

Spotlight

Advertisements