Issue 14, 2021

Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides

Abstract

A green and efficient approach for the synthesis of selenium-substituted iminoisobenzofuran using 2-vinylbenzamides and diselenides in a continuous electrochemical microreactor has been developed. This strategy enabled the preparation of a series of iminoisobenzofuran derivatives in moderate to good yields under metal-free and oxidant-free conditions. The application of the electrochemical flow system successfully overcomes the difficulty of process control in traditional electrochemistry and achieves efficient transformation of electricity. Moreover, the continuous-flow system combined with electrosynthesis overcomes the difficulty in realizing a scale-up reaction in conventional batch-type electrolysis.

Graphical abstract: Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides

Supplementary files

Article information

Article type
Paper
Submitted
06 Nah 2021
Accepted
11 Cig 2021
First published
11 Cig 2021

Org. Biomol. Chem., 2021,19, 3207-3212

Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides

M. Bian, J. Hua, T. Ma, J. Xu, C. Cai, Z. Yang, C. Liu, W. He, Z. Fang and K. Guo, Org. Biomol. Chem., 2021, 19, 3207 DOI: 10.1039/D1OB00236H

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