Hadyn L. Parker, Ruben M. F. Tomás, Christopher M. Furze, Collette S. Guy and Elizabeth Fullam
Org. Biomol. Chem., 2020,18, 3607-3612
DOI:
10.1039/D0OB00253D,
Paper
The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.