Issue 21, 2020

Repurposing of the anti-HIV drug emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization

Abstract

We report supramolecular repurposing of emtricitabine (FTC, trade name: Emtriva®), a blockbuster FDA-approved anti-HIV agent. FTC is revealed to act as a hydrogen-bonded cleft for bipyridine recognition. The supramolecular repurposing is realized by the generation of four cocrystals through liquid-assisted grinding. The clefts comprise discrete three-component assemblies sustained by a combination of hydrogen bonds and π⋯π interactions.

Graphical abstract: Repurposing of the anti-HIV drug emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization

Supplementary files

Article information

Article type
Communication
Submitted
28 Cig 2020
Accepted
06 Cax 2020
First published
06 Cax 2020

CrystEngComm, 2020,22, 3563-3566

Author version available

Repurposing of the anti-HIV drug emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization

G. Campillo-Alvarado, E. A. Keene, D. C. Swenson and L. R. MacGillivray, CrystEngComm, 2020, 22, 3563 DOI: 10.1039/D0CE00474J

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