Issue 6, 2020

Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma

Abstract

Perihilar cholangiocarcinoma (PHCC) presents a formidable challenge due to its occult anatomic location, aggressive growth, insensitivity to conventional chemotherapy, and poor prognosis. Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. The A-NVs@ICG were prepared and exhibited satisfactory targeting effects in HER2-overexpressing PHCC cells. In vivo fluorescence and photoacoustic imaging demonstrated that A-NVs@ICG promoted the accumulation of ICG in PHCC tissue, leading to enhanced tumor regression and improved anti-cancer effects when combined with photoirradiation. Therefore, bio-engineered A-NVs@ICG represent a promising nanotheranostic agent for PHCC with potential for clinical translation.

Graphical abstract: Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma

Supplementary files

Article information

Article type
Communication
Submitted
29 Kax 2019
Accepted
08 Nah 2020
First published
11 Nah 2020

Biomater. Sci., 2020,8, 1575-1579

Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma

X. Zhang, Y. Zhang, Y. Zhang, P. Lv, P. Zhang, C. Chu, J. Mao, X. Wang, W. Li and G. Liu, Biomater. Sci., 2020, 8, 1575 DOI: 10.1039/C9BM02088H

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