Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

Haosha Tang; Yunyan Kuang; Julan Zeng; Xiaofang Li; Wei Zhou; Yuan Lu

doi:10.1039/C9RA06368D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents†

Haosha Tang,^a Yunyan Kuang,^b Julan Zeng,^c Xiaofang Li,^d Wei Zhou

*^b and Yuan Lu*^a

Author affiliations

* Corresponding authors

^a Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai 200011, China

^b Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200433, China
E-mail: zhouw@fudan.edu.cn

^c Department of Chemistry, Changsha University of Science and Technology, Changsha 410114, China

^d School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China

Abstract

Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.

This article is part of the themed collection: Editors' Collection: Fluorine chemistry in medicinal chemistry and chemical biology

Download options Please wait...

Supplementary files

Supplementary information PDF (1430K)

Article information

DOI: https://doi.org/10.1039/C9RA06368D
Article type: Paper
Submitted: 15 Leq 2019
Accepted: 26 Way 2019
First published: 03 Dit 2019
This article is Open Access

Download Citation

RSC Adv., 2019,9, 31474-31482

Permissions

Request permissions

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

H. Tang, Y. Kuang, J. Zeng, X. Li, W. Zhou and Y. Lu, RSC Adv., 2019, 9, 31474 DOI: 10.1039/C9RA06368D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

RSC Advances

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

Social activity

Search articles by author

Spotlight

Advertisements