Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae†
Lisa I.
Pilkington, 
*a
Rebecca C.
Deed,
ab
Katie
Parish-Virtue,
a
Michelle E.
Walker,
c
David
Barker
*a
and
Bruno
Fedrizzi
*a
*a
Rebecca C.
Deed,
ab
Katie
Parish-Virtue,
a
Michelle E.
Walker,
c
David
Barker
*a
and
Bruno
Fedrizzi
*a
Abstract
New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.
- This article is part of the themed collection: 2019 Emerging Investigators
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