Issue 44, 2018

Enhancing the sensitivity of colorimetric lateral flow assay (CLFA) through signal amplification techniques

Abstract

Colorimetric lateral flow assay (CLFA) is one of a handful of diagnostic technologies that can be truly taken out of the laboratory for point-of-care testing without the need for any equipment and skilled personnel. Despite its simplicity and practicality, it remains a grand challenge to substantially enhance the detection sensitivity of CLFA without adding complexity. Such a limitation in sensitivity inhibits many critical applications such as early detection of significant cancers and severe infectious diseases. With the rapid development of materials science and nanotechnology, signal amplification techniques that hold great potential to break through the existing detection limit barrier of CLFA have been developed in recent years. This article specifically highlights these emerging techniques for CLFA development. The rationale behind and advantages and limitations of each technique are discussed. Perspectives on future research directions in this niche and important field are provided.

Graphical abstract: Enhancing the sensitivity of colorimetric lateral flow assay (CLFA) through signal amplification techniques

Article information

Article type
Highlight
Submitted
18 Qas 2018
Accepted
09 Qad 2018
First published
09 Qad 2018

J. Mater. Chem. B, 2018,6, 7102-7111

Author version available

Enhancing the sensitivity of colorimetric lateral flow assay (CLFA) through signal amplification techniques

H. Ye and X. Xia, J. Mater. Chem. B, 2018, 6, 7102 DOI: 10.1039/C8TB01603H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements