Issue 14, 2018

Sulfur mediated propargylic C–H alkylation of alkynes

Abstract

A transition-metal-free, sulfur mediated propargylic C–H alkylation reaction was realized through a one-pot procedure. The reaction design involves an initial addition between alkynes and triflic anhydride activated sulfoxides, and a subsequent [2,3]-sigmatropic rearrangement of the allenyl sulfur ylides generated under basic conditions to give propargylic C–H alkylation products.

Graphical abstract: Sulfur mediated propargylic C–H alkylation of alkynes

Supplementary files

Article information

Article type
Research Article
Submitted
23 Agd 2018
Accepted
04 Qas 2018
First published
05 Qas 2018

Org. Chem. Front., 2018,5, 2167-2170

Sulfur mediated propargylic C–H alkylation of alkynes

G. Hu, J. Xu and P. Li, Org. Chem. Front., 2018, 5, 2167 DOI: 10.1039/C8QO00410B

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