Issue 35, 2018

Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

Abstract

The bifunctional nature of the cinchonidine squaramides has been successfully employed to catalyze the enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones with 2-enoylpyridines under mild reaction conditions. Through this methodology, a broad range of optically active heterocyclic derivatives bearing both pyrazole and pyridine motifs have been synthesized in yields up to 88% and enantiomeric excess up to 96%.

Graphical abstract: Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

Supplementary files

Article information

Article type
Paper
Submitted
06 Qad 2018
Accepted
17 Leq 2018
First published
17 Leq 2018

Org. Biomol. Chem., 2018,16, 6470-6478

Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

V. Sharma, A. Kaur, S. C. Sahoo and S. S. Chimni, Org. Biomol. Chem., 2018, 16, 6470 DOI: 10.1039/C8OB01588K

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