Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier; J. Mayr; G. Koellensperger; B. K. Keppler; C. R. Kowol; U. Karst

doi:10.1039/C8AN00258D

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)†

L. M. Frensemeier,^a J. Mayr,^b G. Koellensperger,^c B. K. Keppler,^b C. R. Kowol

*^b and U. Karst

*^a

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* Corresponding authors

^a Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany
E-mail: christian.kowol@univie.ac.at, uk@uni-muenster.de

^b Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria

^c Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria

Abstract

Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.

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DOI: https://doi.org/10.1039/C8AN00258D
Article type: Communication
Submitted: 09 Nah 2018
Accepted: 29 Cig 2018
First published: 09 Agd 2018
This article is Open Access

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Analyst, 2018,143, 1997-2001

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Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol and U. Karst, Analyst, 2018, 143, 1997 DOI: 10.1039/C8AN00258D

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Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)†

Abstract

Supplementary files

Article information

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Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

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