Palladium-catalyzed asymmetric allylic amination: enantioselective synthesis of chiral α-methylene substituted β-aminophosphonates

Abstract

Spiroketal backbone based diphosphine ligands (SKP) were disclosed to be highly efficient and enantioselective (94 → 99% ee) in the palladium catalyzed asymmetric allylic amination of 2-diethylphosphonate-substituted allylic acetates, affording a series of chiral β-aminophosphonates bearing an α-methylene functionality in high yields with excellent regioselectivities.