Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Adam C. Sedgwick; Hai-Hao Han; Jordan E. Gardiner; Steven D. Bull; Xiao-Peng He; Tony D. James

doi:10.1039/C7CC07845E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite†

Adam C. Sedgwick,

*^a Hai-Hao Han,^b Jordan E. Gardiner,

^a Steven D. Bull,

*^a Xiao-Peng He

*^b and Tony D. James

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk, s.d.bull@bath.ac.uk

^b Key Laboratory for Advanced Materials & Feringa Nobel Prize Scientist Joint Research Center, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

This article is part of the themed collection: Chemosensors and Molecular Logic

Download options Please wait...

Supplementary files

Supplementary information PDF (676K)

Article information

DOI: https://doi.org/10.1039/C7CC07845E
Article type: Communication
Submitted: 10 Dit 2017
Accepted: 03 Xim 2017
First published: 08 Xim 2017
This article is Open Access

Download Citation

Chem. Commun., 2017,53, 12822-12825

Permissions

Request permissions

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

A. C. Sedgwick, H. Han, J. E. Gardiner, S. D. Bull, X. He and T. D. James, Chem. Commun., 2017, 53, 12822 DOI: 10.1039/C7CC07845E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Social activity

Search articles by author

Spotlight

Advertisements