Issue 34, 2016
From the journal:

Journal of Materials Chemistry B

Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs†

Yuming Guo,*ab   Weili Jia,a   Han Li,a   Weike Shi,a   Jie Zhang,a   Jing Fenga  and  Lin Yang*ab  

* Corresponding authors

a Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China
E-mail: guoyuming@htu.edu.cn, yanglin1819@163.com

b Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China

Abstract

Biocompatible hybrid hollow spheres of calcium carbonate/folate with both mesopores and macropores were synthesized using a facile green approach based on Ostwald ripening. The porous hollow spheres were efficiently loaded with doxorubicin, which they were then able to release in a pH-responsive and sustained manner for the targeted treatment of human cancer cells.

Graphical abstract: Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C6TB01483F
Article type
Communication
Submitted
16 Qas 2016
Accepted
24 Qad 2016
First published
25 Qad 2016

J. Mater. Chem. B, 2016,4, 5650-5653

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Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

Y. Guo, W. Jia, H. Li, W. Shi, J. Zhang, J. Feng and L. Yang, J. Mater. Chem. B, 2016, 4, 5650 DOI: 10.1039/C6TB01483F

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