Issue 23, 2016

Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

Abstract

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

Graphical abstract: Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

Supplementary files

Article information

Article type
Communication
Submitted
30 Qun 2016
Accepted
25 Nah 2016
First published
25 Nah 2016

Chem. Commun., 2016,52, 4389-4392

Author version available

Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

S. Roy, N. R. Goud and A. J. Matzger, Chem. Commun., 2016, 52, 4389 DOI: 10.1039/C6CC00959J

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