Issue 13, 2016
From the journal:

Analyst

Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors†

Gunnar Dunér,ab   Henrik Anderson,bc   Zhichao Pei,b   Björn Ingemarsson,b   Teodor Aastrupb  and  Olof Ramström*a  

* Corresponding authors

a KTH – Royal Institute of Technology, Department of Chemistry, Teknikringen 30, S-10044 Stockholm, Sweden
E-mail: ramstrom@kth.se

b Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden

c Uppsala University, Ångström Laboratory, Solid State Electronics, P.O. Box 534, S-75121 Uppsala, Sweden

Abstract

The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin Fab fragment. The poly(acrylic acid) sensors showed a dramatic increase in signal response with more than ten times higher signal than the carboxyl-terminated self-assembled monolayer surface.

Graphical abstract: Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors

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Article information

DOI
https://doi.org/10.1039/C6AN00735J
Article type
Communication
Submitted
29 Cig 2016
Accepted
11 Cax 2016
First published
12 Cax 2016
This article is Open Access
Creative Commons BY-NC license

Analyst, 2016,141, 3993-3996

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Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors

G. Dunér, H. Anderson, Z. Pei, B. Ingemarsson, T. Aastrup and O. Ramström, Analyst, 2016, 141, 3993 DOI: 10.1039/C6AN00735J

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