Issue 10, 2015

Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold

Abstract

The adamantyl group is prevalent as a key pharmacophore element in drugs. We describe herein a palladium-catalyzed C–H functionalization logic for the methylene C(sp3)–H arylation of the adamantyl scaffold with the assistance of an amide group. The resulting arylated adamantyl amide was smoothly converted to an amine, providing facile access to the memantine analog.

Graphical abstract: Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold

Supplementary files

Article information

Article type
Research Article
Submitted
09 Qad 2015
Accepted
13 Leq 2015
First published
14 Leq 2015

Org. Chem. Front., 2015,2, 1374-1378

Author version available

Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold

Y. Lao, J. Wu, Y. Chen, S. Zhang, Q. Li and H. Wang, Org. Chem. Front., 2015, 2, 1374 DOI: 10.1039/C5QO00218D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements