Issue 4, 2015
From the journal:

Organic Chemistry Frontiers

Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates†‡

Takanori Shibata*ab  and  Hideaki Takanoa  

* Corresponding authors

a Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan
E-mail: tshibata@waseda.jp
Fax: (+81) 3-5286-8098

b JST, ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

Abstract

The reaction of 2-arylmethyl-, 2-aryl-, and 2-alkyl substituted pyridine N-oxides with acrylates proceeded in the presence of a cationic Ir-rac-BINAP catalyst under heating conditions. Various 2,6-disubstituted pyridine N-oxides were obtained by C–H alkylation at the C6-position.

Graphical abstract: Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4QO00355A
Article type
Research Article
Submitted
30 Kax 2014
Accepted
09 Nah 2015
First published
11 Nah 2015

Org. Chem. Front., 2015,2, 383-387

Author version available

Download author version (PDF)

Permissions

Request permissions

Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

T. Shibata and H. Takano, Org. Chem. Front., 2015, 2, 383 DOI: 10.1039/C4QO00355A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements