Issue 11, 2014

Efficient access to 1H-indazoles via copper-catalyzed cross-coupling/cyclization of 2-bromoaryl oxime acetates and amines

Abstract

We describe a novel and useful method to provide 1H-indazoles via copper-catalyzed tandem reaction which is triggered by an Ullmann-type reaction and followed by N–N bond formation. Arylamines, alkylamines and sulfonamides could smoothly couple with 2-bromoaryl oxime acetates and various 1H-indazoles were formed in good to excellent yields under mild reaction conditions.

Graphical abstract: Efficient access to 1H-indazoles via copper-catalyzed cross-coupling/cyclization of 2-bromoaryl oxime acetates and amines

Supplementary files

Article information

Article type
Research Article
Submitted
08 Way 2014
Accepted
11 Xim 2014
First published
12 Xim 2014

Org. Chem. Front., 2014,1, 1295-1298

Author version available

Efficient access to 1H-indazoles via copper-catalyzed cross-coupling/cyclization of 2-bromoaryl oxime acetates and amines

X. Tang, H. Gao, J. Yang, W. Wu and H. Jiang, Org. Chem. Front., 2014, 1, 1295 DOI: 10.1039/C4QO00244J

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