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Hydroxyapatite (HAp) nanocrystals with excellent biocompatibility and bioresorbability are usually used in the fields of tissue engineering, medicine, etc. In this review, recent advances in the tunable synthesis, ion doping, assembly and applications of monodisperse HAp nanocrystals are summarized, which may be helpful for the designed synthesis and surface modification of HAp or other nanocrystals according to practical applications.

Graphical abstract: Hydroxyapatite nanocrystals: colloidal chemistry, assembly and their biological applications

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