Alhosna Benjdia, Korbinian Heil, Andreas Winkler, Thomas Carell and Ilme Schlichting
Chem. Commun., 2014,50, 14201-14204
DOI:
10.1039/C4CC05158K,
Communication
The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.
