Issue 40, 2014

68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Abstract

We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Graphical abstract: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Supplementary files

Article information

Article type
Communication
Submitted
16 Kax 2013
Accepted
19 Nah 2014
First published
21 Nah 2014

Chem. Commun., 2014,50, 5215-5217

Author version available

68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

B. Nichols, Z. Qin, J. Yang, D. R. Vera and N. K. Devaraj, Chem. Commun., 2014, 50, 5215 DOI: 10.1039/C3CC49530B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements