A simple rhodium(II) complex catalyzes cysteine modification with diazo reagents. The reaction is marked by clean cysteine selectivity and mild reaction conditions. The resulting linkage is significantly more stable in human plasma serum, when compared to common maleimide reagents.
R. Kundu and Z. T. Ball, Chem. Commun., 2013, 49, 4166 DOI: 10.1039/C2CC37323H
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