Issue 14, 2024

Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

Abstract

Electrospray-related ion sources are promising for direct mass spectrometric analysis of complex samples, but current protocols suffer from complicated components and low analytical sensitivity. Here, we propose a surface charge-induced electrospray ionization (SCIESI) inspired by flashover on an insulator surface under high voltage. This protocol not only effectively avoids contact between the sample solution and metal electrode, but also allows completion of the entire analytical process in less than 40 seconds and limits of detection in the pictogram per milliliter range. SCIESI coupled to mass spectrometry can also be used to monitor electro-chemical processes, and a number of oxidation and reduction reactions have been studied, demonstrating that it is a powerful tool for understanding electrochemical reaction mechanisms.

Graphical abstract: Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

Supplementary files

Article information

Article type
Communication
Submitted
16 Nah 2024
Accepted
09 Cig 2024
First published
11 Cig 2024

Anal. Methods, 2024,16, 2002-2008

Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

Y. Huang, Y. Zheng, Q. Zuo, Z. Zhang, L. Zhu, Y. Li and Z. Zhang, Anal. Methods, 2024, 16, 2002 DOI: 10.1039/D4AY00276H

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