A reaction for H–F bond insertion into α-diazo carbonyl compounds is reported. The protocol describes a simple reaction setup employing commercially available HF·pyr (Olah reagent) as the fluorine source. The method is rapid and practical, and allows access to a broad range of α-fluorinated carbonyl compounds in generally good yields.
L. S. Munaretto, R. D. C. Gallo, L. P. M. O. Leão and I. D. Jurberg, Org. Biomol. Chem., 2022, 20, 6178 DOI: 10.1039/D2OB00400C
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