Issue 19, 2022

semiaza-Bambusurils are anion-specific transmembrane transporters

Abstract

semiaza-Bambus[6]urils efficiently transport anions across lipid membranes. A systematic modification of their lipophilic side chains to include various alkyl groups and thioethers reveals that the most efficient chloride transporters are those that agree with Lipinski's rule-of-lipophilicity, exhibiting clog Po/w values close to 5. Furthermore, vesicle anion-transport assays show that the new anion-transporters are independent of the cation identity but exhibit high anion selectivity, NO3 > Br > Cl > SO42−, in agreement with the Hofmeister series. These findings will allow for the design of highly specific anion transporters for biomedical applications, particularly for managing anion channelopathies.

Graphical abstract: semiaza-Bambusurils are anion-specific transmembrane transporters

Supplementary files

Article information

Article type
Communication
Submitted
08 Qun 2022
Accepted
08 Nah 2022
First published
08 Nah 2022

Chem. Commun., 2022,58, 3150-3153

semiaza-Bambusurils are anion-specific transmembrane transporters

R. Khurana, F. Yang, R. Khurana, J. Liu, E. Keinan and O. Reany, Chem. Commun., 2022, 58, 3150 DOI: 10.1039/D2CC00144F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements