Issue 11, 2021

Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones

Abstract

A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52–90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

Graphical abstract: Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones

Supplementary files

Article information

Article type
Paper
Submitted
07 Kax 2020
Accepted
25 Nah 2021
First published
26 Nah 2021

Org. Biomol. Chem., 2021,19, 2481-2486

Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones

M. Zhang, T. Chen, S. Fang, W. Wu, X. Wang, H. Wu, Y. Xiong, J. Song, C. Li, Z. He and C. Lee, Org. Biomol. Chem., 2021, 19, 2481 DOI: 10.1039/D0OB02444A

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