Issue 48, 2018

Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

Abstract

We show that the chemoselectivity of an electrophile in protein labeling can be promiscuous. An aldehyde enables switching of chemoselectivity of an epoxide and a sulfonate ester along with an enhanced rate of reaction. The chemical technology renders single-site installation of diverse probes on a protein and delivers analytically pure tagged proteins.

Graphical abstract: Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

Supplementary files

Article information

Article type
Communication
Submitted
20 Xim 2018
Accepted
28 Xim 2018
First published
28 Xim 2018

Org. Biomol. Chem., 2018,16, 9377-9381

Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

S. R. Adusumalli, D. G. Rawale and V. Rai, Org. Biomol. Chem., 2018, 16, 9377 DOI: 10.1039/C8OB02897D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements