Issue 19, 2017

New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

Abstract

This work describes an efficient process for the reduction of nitro compounds to the corresponding amines with a catalytic amount of Pd/C (0.6 mol%), and a mixture of sodium hypophosphite and hypophosphorous acid as a reducing agent in H2O/2-MeTHF at 60 °C. The reaction was optimized under silent conditions. The conditions for the in situ production of H2 using the mixture NaH2PO2/H3PO2 were studied. The influence of ultrasonic activation was investigated both in terms of efficiency and kinetics. The reaction was shown to be efficient in water, at 70 °C with a quantitative conversion and a maximal yield in only 15 min thanks to the ultrasonic activation. Finally, ultrasound was proved to act as a physical agent of phase transfer.

Graphical abstract: New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

Supplementary files

Article information

Article type
Paper
Submitted
02 Qas 2017
Accepted
14 Leq 2017
First published
14 Leq 2017

Green Chem., 2017,19, 4583-4590

New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

S. Letort, M. Lejeune, N. Kardos, E. Métay, F. Popowycz, M. Lemaire and M. Draye, Green Chem., 2017, 19, 4583 DOI: 10.1039/C7GC01622K

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