Issue 19, 2016

Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

Abstract

A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models. Together with in vivo efficacy studies, our results demonstrate that TPGS is not only critical to stabilize the mixed micelle structure but also to improve drug loading and facilitate cell penetration and accumulation.

Graphical abstract: Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

Supplementary files

Article information

Article type
Paper
Submitted
27 Nah 2016
Accepted
17 Cig 2016
First published
17 Cig 2016

J. Mater. Chem. B, 2016,4, 3216-3224

Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

X. Cao, X. Zhou, Y. Wang, T. Gong, Z. Zhang, R. Liu and Y. Fu, J. Mater. Chem. B, 2016, 4, 3216 DOI: 10.1039/C6TB00508J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements