Issue 98, 2016
From the journal:

RSC Advances

Synthesis of 3-arylindole derivatives from nitroalkane precursors†

Chia-Yu Huang,‡a   Chun-Wei Kuo,‡a   Ashok Konala,a   Tang-Hao Yang,a   Lyu Lin,a   Yu-Wen Chen,a   Veerababurao Kavalaa  and  Ching-Fa Yao*a  

* Corresponding authors

a Department of Chemistry, National Taiwan Normal University, 88, section 4, Tingchow road, Taipei, Taiwan 116, Republic of China
E-mail: cheyaocf@ntnu.edu.tw

Abstract

3-Arylindole derivatives were synthesized by Cu(I) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel–Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

Graphical abstract: Synthesis of 3-arylindole derivatives from nitroalkane precursors

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Article information

DOI
https://doi.org/10.1039/C6RA21144E
Article type
Paper
Submitted
23 Leq 2016
Accepted
02 Dit 2016
First published
03 Dit 2016

RSC Adv., 2016,6, 96049-96056

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Synthesis of 3-arylindole derivatives from nitroalkane precursors

C. Huang, C. Kuo, A. Konala, T. Yang, L. Lin, Y. Chen, V. Kavala and C. Yao, RSC Adv., 2016, 6, 96049 DOI: 10.1039/C6RA21144E

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