Issue 58, 2016
From the journal:

Chemical Communications

Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts†

Markus Müllner,*a   Dharmini Mehta,bc   Cameron J. Nowelld  and  Christopher J. H. Porter ORCID logo bc  

* Corresponding authors

a Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney 2006, New South Wales, Australia
E-mail: markus.muellner@sydney.edu.au

b Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia

c ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia

d Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia

Abstract

The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.

Graphical abstract: Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

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Article information

DOI
https://doi.org/10.1039/C6CC00447D
Article type
Communication
Submitted
16 Qun 2016
Accepted
17 Cig 2016
First published
29 Cig 2016

Chem. Commun., 2016,52, 9121-9124

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Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

M. Müllner, D. Mehta, C. J. Nowell and C. J. H. Porter, Chem. Commun., 2016, 52, 9121 DOI: 10.1039/C6CC00447D

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