Issue 5, 2015

Continuous flow microfluidic solution for quantitative analysis of active pharmaceutical ingredient content and kinetic release

Abstract

Counterfeit and substandard medicines are a grave public health concern that comprises a multibillion-dollar black market and claims over 100 000 lives every year. The World Health Organization estimates that 1–50% of medicines in countries around the world are adulterated, and their presence imposes serious financial and economic burdens while also contributing to the rise of drug-resistant pathogens. Although there are a number of technologies available for field-based quality screening, none can reliably quantify active pharmaceutical ingredient (API) content or kinetic release from a dissolving tablet at the point of care. This work presents an alternative analytical technique to address this major gap. Our system can specifically and accurately quantify drug API content and kinetic release using a portable, inexpensive, and easy-to-use aptamer based fluorescence platform. We demonstrate that aptamers can provide a simple and effective way to target a wide range of APIs, while maintaining high quantitative precision and accuracy. A microfluidic, flow-through system is employed to obtain drug quality information using a single step procedure that shows an accuracy of over 97% for both API quantification and kinetic release.

Graphical abstract: Continuous flow microfluidic solution for quantitative analysis of active pharmaceutical ingredient content and kinetic release

Supplementary files

Article information

Article type
Paper
Submitted
04 Kax 2014
Accepted
06 Qun 2015
First published
19 Qun 2015

Anal. Methods, 2015,7, 1914-1923

Author version available

Continuous flow microfluidic solution for quantitative analysis of active pharmaceutical ingredient content and kinetic release

D. Desai and M. H. Zaman, Anal. Methods, 2015, 7, 1914 DOI: 10.1039/C4AY02884H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements