Issue 43, 2012

Designing organometallic compounds for catalysis and therapy

Abstract

Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation. Electronic and steric effects are used to control both the thermodynamics and kinetics of ligand substitution and redox reactions of metal ions, especially RuII. Can similar features be incorporated into the design of targeted organometallic drugs? Such complexes offer potential for novel mechanisms of drug action through incorporation of outer-sphere recognition of targets and controlled activation features based on ligand substitution as well as metal- and ligand-based redox processes. We focus here on η6-arene, η5-cyclopentadienyl sandwich and half-sandwich complexes of FeII, RuII, OsII and IrIII with promising activity towards cancer, malaria, and other conditions.

Graphical abstract: Designing organometallic compounds for catalysis and therapy

Article information

Article type
Feature Article
Submitted
31 Qun 2012
Accepted
20 Cig 2012
First published
19 Agd 2012

Chem. Commun., 2012,48, 5219-5246

Designing organometallic compounds for catalysis and therapy

A. L. Noffke, A. Habtemariam, A. M. Pizarro and P. J. Sadler, Chem. Commun., 2012, 48, 5219 DOI: 10.1039/C2CC30678F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements