Themed collection Journal of Materials Chemistry B HOT Papers
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Chemical and molecular tools to probe biological sex differences at multiple length scales
Sex differences in biology are observed at multiple different length scales and across organ systems.
J. Mater. Chem. B, 2022,10, 7089-7098
https://doi.org/10.1039/D2TB00871H
Cell membrane-engineered nanoparticles for cancer therapy
This review mainly summarizes the research progress of cell membrane extraction and coating technology, with an emphasis on the treatment of cancer with cell membrane-engineered nanoparticles from various sources.
J. Mater. Chem. B, 2022,10, 7161-7172
https://doi.org/10.1039/D2TB00709F
Rational construction of polycystine-based nanoparticles for biomedical applications
This review summarizes the development of reduction-responsive disulfide-crosslinked PCys2-based nanoparticles through one-pot polymerization, post-polymerization modification, and post-polymerization self-assembly for biomedical applications.
J. Mater. Chem. B, 2022,10, 7173-7182
https://doi.org/10.1039/D2TB00581F
Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management
This review provides the recent progress, intrinsic interactions between structures and bioactive performances, current limitations and future directions of bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management.
J. Mater. Chem. B, 2022,10, 7148-7160
https://doi.org/10.1039/D2TB00591C
Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation
This review focuses on the recent advances in hydrogels for the 3D culture of MSCs and the current/potential applications of 3D hydrogel culture systems, providing preliminary tips for designing hydrogel culture systems with special properties.
J. Mater. Chem. B, 2022,10, 1486-1507
https://doi.org/10.1039/D1TB02537F
Upconversion-nanoparticle-functionalized Janus micromotors for efficient detection of uric acid
We developed enzyme-powered UCNP-functionalized Janus micromotors. These micromotors display efficient motion in urine powered by biocatalytic decomposition of uric acid and simultaneously detect uric acid based on the luminescence quenching effect.
J. Mater. Chem. B, 2022,10, 358-363
https://doi.org/10.1039/D1TB02550C
A co-formulated vaccine of irradiated cancer cells and cowpea mosaic virus improves ovarian cancer rejection
Cowpea mosaic virus adjuvants bind to irradiated cancer cells (ICCs) – the co-delivery of ICCs (the antigen) and CPMV (the adjuvant) demonstrates potent efficacy as a vaccine that protects mice from ovarian tumor challenge.
J. Mater. Chem. B, 2023,11, 5429-5441
https://doi.org/10.1039/D2TB02355E
Ultrasensitive photoelectrochemical biosensing platform based target-triggered biocatalytic precipitation reactions on a flower-like Bi2O2S super-structured photoanode
Herein, we reported a novel photoelectrochemical immunoassay method based on a target-triggered on/off signal of the ultra-structured Bi2O2S (BOS) photoanode system for the sensitive testing of carcinoembryonic antigen (CEA) in serum samples.
J. Mater. Chem. B, 2022,10, 10018-10026
https://doi.org/10.1039/D2TB02283D
A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity
A poly-2-hydroxyethyl methacrylate functionalized biological heart valve with enhanced biocompatibility, antithrombogenicity and anticalcification property.
J. Mater. Chem. B, 2022,10, 10001-10017
https://doi.org/10.1039/D2TB02218D
Construction of a phos-tag-directed self-assembled fluorescent magnetobiosensor for the simultaneous detection of multiple protein kinases
We construct a phos-tag-directed self-assembled fluorescent magnetobiosensor to simultaneously detect multiple protein kinases with good selectivity and high sensitivity.
J. Mater. Chem. B, 2022,10, 9992-10000
https://doi.org/10.1039/D2TB01820A
Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy
An amino acid based- supramolecular nanomedicine is constructed based on multicomponent coordination self-assembly for tumor cascade- activated and -amplified synergetic catalytic-chemotherapy, which achieved efficient tumor growth suppression.
J. Mater. Chem. B, 2022,10, 9838-9847
https://doi.org/10.1039/D2TB02326A
Multifunctional theragnostic ultrasmall gold nanodot-encapsuled perfluorocarbon nanodroplets for laser-focused ultrasound sequence irradiation (LFSI)-based enhanced tumor ablation
Multifunctional ultrasmall Au nanodots-loaded perfluorocarbon nanodroplets (Au-PFCnDs) were prepared for enhanced tumor ablation therapy via a facile laser-focused ultrasound sequence irradiation (LFSI) method.
J. Mater. Chem. B, 2022,10, 9816-9829
https://doi.org/10.1039/D2TB01775J
Conjugated/nonconjugated alternating copolymers for enhanced NIR-II fluorescence imaging and NIR-II photothermal-ferrotherapy
A new class of conjugated/nonconjugated alternating copolymers is reported by introducing nonconjugated linkers into a conjugated backbone. This newly developed CNACPs is prepared for NIR-II FI-guided NIR-II PTT/ferrotherapy synergistic therapy.
J. Mater. Chem. B, 2022,10, 9830-9837
https://doi.org/10.1039/D2TB01567F
Sheet-like Janus hemostatic dressings with synergistic effects of cardanol hemostasis and quaternary ammonium salt antibacterial action
A sheet-like silica-based hemostatic dressing with an asymmetrical Janus structure was prepared, which has biological safety. Both sides of the Janus material play two aspects of rapid hemostasis and efficient antibacterial activity independently.
J. Mater. Chem. B, 2022,10, 9413-9423
https://doi.org/10.1039/D2TB02082C
A biomimetic double network hydrogel ameliorates renal fibrosis and promotes renal regeneration
A bioinspired double network hydrogel scaffold (GCS) loaded with curcumin and N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) was prepared. This cyto-favorable hydrogel could prevent renal fibrosis, promote renal injury repair and renal regeneration.
J. Mater. Chem. B, 2022,10, 9424-9437
https://doi.org/10.1039/D2TB01939F
Highly stretchable, self-healing elastomer hydrogel with universal adhesion driven by reversible cross-links and protein enhancement
A multifunctional hydrogel comprising covalent reversibly cross-linked PHEMAA and available deformable casein micelles was developed integrating high stretchability, toughness, low hysteresis, self-healing and adhesion into a system simultaneously.
J. Mater. Chem. B, 2022,10, 9188-9201
https://doi.org/10.1039/D2TB02015G
Nano-assemblies of phosphonium-functionalized diblock copolymers with fabulous antibacterial properties and relationships of structure-activity
Phosphonium functionalized diblock copolymers are prepared through the RAFT PISA method which creates nano-assemblies with various special micromorphology and presents fabulous antibacterial activity in relation to the polymer structure.
J. Mater. Chem. B, 2022,10, 9202-9215
https://doi.org/10.1039/D2TB01778D
A vinyl-decorated covalent organic framework for ferroptotic cancer therapy via visible-light-triggered cysteine depletion
Intracellular cysteine depletion induced by a COF-based click photoreaction achieves effective cancer therapy by ferroptosis.
J. Mater. Chem. B, 2022,10, 8894-8909
https://doi.org/10.1039/D2TB01815B
Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO
Hollow mesoporous CuO nanozyme with GSH-depletion enhanced the enzyme catalytic activity for photothermal-assisted bacterial killing.
J. Mater. Chem. B, 2022,10, 8883-8893
https://doi.org/10.1039/D2TB01621D
One-pot synthesis of efficient multifunctional nitrogen-doped carbon dots with efficient yellow fluorescence emission for detection of hypochlorite and thiosulfate
CD-based ratiometric fluorescence probes are of great significance for visual detection, but accomplishing this goal is still a particularly challenging task.
J. Mater. Chem. B, 2022,10, 8910-8917
https://doi.org/10.1039/D2TB01695H
A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment
The mechanically robust estradiol-loaded PHMH-Si hydrogel could not only release estradiol sustainably and locally but also be a mechanically robust and stable barrier in the uterine cavity, which may be a novel and effective treatment for IUAs.
J. Mater. Chem. B, 2022,10, 8684-8695
https://doi.org/10.1039/D2TB01740G
Hydrogen sulfide-releasing polyurethane/gelatin/keratin–TA conjugate mats for wound healing
A keratin-thiobenzoic acid conjugate (KTC) was synthesized and incorporated with PU and gelatin to fabricate nanofibrous mats. These mats were capable of releasing H2S in a sustained way, which could increase the antioxidant ability and wound healing effect prominently.
J. Mater. Chem. B, 2022,10, 8672-8683
https://doi.org/10.1039/D2TB01700H
Multifunctional nanoreactors with nutrient consumption and ROS generation capabilities for antibacterial and skin repair
A multifunctional nanoreactor (GOx@Cu-ZIF-8) with nutrient consumption, reactive oxygen species generation, and angiogenesis capabilities was constructed by the encapsulation of GOx into Cu2+-doped ZIF-8 for antibacterial and skin wound repair.
J. Mater. Chem. B, 2022,10, 8664-8671
https://doi.org/10.1039/D2TB01436J
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Detachment of bovine corneal endothelial cell sheets by cooling-induced surface hydration of poly[(R)-3-hydroxybutyrate]-based thermoresponsive copolymer coating
A smart surface was prepared by non-covalently coating of a thermoresponsive copolymer via a simple drop-casting method. The smart surface was conducive to cell culture, from which intact cell sheets could be effectively detached by cooling.
J. Mater. Chem. B, 2022,10, 8407-8418
https://doi.org/10.1039/D2TB01926D
Design of foldable, responsively drug-eluting polyacrylic intraocular lens bulk materials for prevention of postoperative complications
An anti-proliferative drug was conjugated into bulk material via Schiff base bond to construct a pH-responsive drug-eluting IOL. The pH-responsive drug-eluting IOL can effectively prevent posterior capsular opacification after implantation.
J. Mater. Chem. B, 2022,10, 8398-8406
https://doi.org/10.1039/D2TB01974D
Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification
The synergistic strategy of sulfonated, oxidized pectin and quercetin can enhance the BVLs’ mechanical properties and also endow BVLs with excellent hemocompatibility, anti-inflammatory, anti-calcification, and pro-endothelialization.
J. Mater. Chem. B, 2022,10, 8218-8234
https://doi.org/10.1039/D2TB01704K
Early diagnostic imaging of pneumonia with an ultra-sensitive two-photon near-infrared fluorescent probe
The mortality rate of pneumonia increases significantly with the prolongation of illness.
J. Mater. Chem. B, 2022,10, 8186-8192
https://doi.org/10.1039/D2TB01687G
Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy
DOX@CREKA/tPA–HP modulates tumor mechanical properties by decomposing intratumoral fibrin, thereby decompressing tumor blood vessels, facilitating drug delivery, and augmenting antitumor effect.
J. Mater. Chem. B, 2022,10, 8193-8210
https://doi.org/10.1039/D2TB01812H
Capture and detection of Escherichia coli with graphene aerogels
We constructed a biosensor for detecting E. coli using a 3D graphene aerogel as the detection substrate. The detection limit of E. coli can be as low as 10 cfu mL−1.
J. Mater. Chem. B, 2022,10, 8211-8217
https://doi.org/10.1039/D2TB01749K
Tailoring head–tail mesoporous silica nanoparticles for enhanced gene transfection
Asymmetric silica nanoparticles featuring a unique head–tail morphology are engineered for efficient gene transfection with the impact of particle tail length on DNA delivery studied, guiding rational design of asymmetric non-viral gene vectors.
J. Mater. Chem. B, 2022,10, 7995-8002
https://doi.org/10.1039/D2TB01737G
Superhydrophilic nanocomposite adsorbents modified via nitrogen-rich phosphonate-functionalized ionic liquid linkers: enhanced phosphopeptide enrichment and phosphoproteome analysis of tau phosphorylation in the hippocampal lysate of Alzheimer's transgenic mice
The superhydrophilic nanocomposite G@mSiO2@PEI-PFIL-Ti4+ can be use as a platform to enrich phosphopeptides in ultralow abundance from real complicated bio-samples for a phosphoproteomic study.
J. Mater. Chem. B, 2022,10, 7967-7978
https://doi.org/10.1039/D2TB01508K
A zwitterionic silver nanoparticle-incorporating injectable hydrogel with a durable and efficient antibacterial effect for accelerated wound healing
A facile stabilization strategy for silver nanoparticles is developed for an antibacterial and injectable hydrogel to promote wound healing.
J. Mater. Chem. B, 2022,10, 7979-7994
https://doi.org/10.1039/D2TB01493A
A diselenium-bridged covalent organic framework with pH/GSH/photo-triple-responsiveness for highly controlled drug release toward joint chemo/photothermal/chemodynamic cancer therapy
A novel joint chemo/photothermal/chemodynamic therapy was developed using a pH/GSH/photo triple-responsive 2D-covalent organic framework (Di-Se-Por) as a drug carrier for the passive target treatment of tumors with extraordinarily high efficiency.
J. Mater. Chem. B, 2022,10, 7955-7966
https://doi.org/10.1039/D2TB01015A
The role of nanopores constructed on the micropitted titanium surface in the immune responses of macrophages and the potential mechanisms
The micropit/nanopore surface constructed on titanium displays the ability to polarize macrophages to the pro-healing M2 phenotype.
J. Mater. Chem. B, 2022,10, 7732-7743
https://doi.org/10.1039/D2TB01263D
Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles
The illustration of PPT and PDT of FRuNPs and their phototherapy procedure in vitro and in vivo.
J. Mater. Chem. B, 2022,10, 7760-7771
https://doi.org/10.1039/D2TB01276F
A biofilm microenvironment-responsive one-for-all bactericidal nanoplatform for photothermal-augmented multimodal synergistic therapy of pathogenic bacterial biofilm infection
We rationally construct a biofilm microenvironment-responsive bactericidal nanoplatform (ZnPMp) consisting of ZnO core, a Fe3+-doped polydopamine coating and methylene blue (MB) payload for combined CT/CDT/PTT/PDT multi-mode antibacterial therapy.
J. Mater. Chem. B, 2022,10, 7744-7759
https://doi.org/10.1039/D2TB01200F
Biosafety evaluation of dual-responsive neutrobots
Neutrobots carrying antitumor drugs facilitate considerable safety in vivo upon intravenous administration with high dose.
J. Mater. Chem. B, 2022,10, 7556-7562
https://doi.org/10.1039/D2TB00938B
Exploration of multifunctional wood coating based on an interpenetrating network system of rosin-CO2-based polyurethane and mussel bionic rosin-based benzoxazine
Polyurethane (PU) prepared by blending rosin base and CO2-polyol already has good mechanical properties and hydrophobic effect and has powerful benefits in acid and alkali resistance and salt resistance.
J. Mater. Chem. B, 2022,10, 6939-6945
https://doi.org/10.1039/D2TB01535H
Silkworm spinning inspired 3D printing toward a high strength scaffold for bone regeneration
Inspired by silkworm spinning, we fabricated silk fibroin-hydroxyapatite self-assembling and dense nanostructures composite scaffolds for bone regeneration by 3D printing, and the maximum compressive strength of the scaffold reaches up to 166 MPa.
J. Mater. Chem. B, 2022,10, 6946-6957
https://doi.org/10.1039/D2TB01161A
Development of a microfluidic dispensing device for multivariate data acquisition and application in molecularly imprinting hydrogel preparation
We fabricated microfluidic dispensing devices, which can give the solution of different flow rates, successfully acquiring multivariate data on the adsorption capacity for protein imprinting hydrogels.
J. Mater. Chem. B, 2022,10, 6664-6672
https://doi.org/10.1039/D2TB00685E
An artificial antibody for exosome capture by dull template imprinting technology
Benefiting from the synergistic effect of dull template imprinting and electrostatic interaction, the artificial antibody can capture exosomes from biofluids.
J. Mater. Chem. B, 2022,10, 6655-6663
https://doi.org/10.1039/D2TB00494A
Glycine assists in efficient synthesis of herbal carbon dots with enhanced yield and performance
As a special type of biomass, herbal medicine often contains a variety of biologically active substances, and taking it as carbon source, it is expected to produce various types of biologically functional carbon dots (CDs). In addition, glycine is helpful to the efficient synthesis of herbal CDs.
J. Mater. Chem. B, 2022,10, 6433-6442
https://doi.org/10.1039/D2TB01334G
Oxygen-powered flower-like FeMo6@CeO2 self-cascade nanozymes: a turn-on enhancement fluorescence sensor
A novel integrated nanozyme (FeMo6@CeO2) is synthesized. It was found that the effect on the substrate adsorption capacity due to specific surface area was more significant than active site exposure for cascade mimetic enzyme activity.
J. Mater. Chem. B, 2022,10, 6425-6432
https://doi.org/10.1039/D2TB01466A
Tough complex hydrogels transformed from highly swollen polyelectrolyte hydrogels based on Cu2+ coordination with anti-bacterial properties
The synthesis of tough hydrogels based on metal coordination between Cu2+ and a phosphorus-containing cationic polyelectrolyte for wound dressing is reported, exhibiting excellent anti-bacterial performance and biocompatibility.
J. Mater. Chem. B, 2022,10, 6414-6424
https://doi.org/10.1039/D2TB00830K
Reversal of cisplatin chemotherapy resistance by glutathione-resistant copper-based nanomedicine via cuproptosis
A copper nanomedicine shows the glutathione-resistant anticancer effect and reverses cisplatin chemotherapy resistance in non-small-cell lung cancer by cuproptosis.
J. Mater. Chem. B, 2022,10, 6296-6306
https://doi.org/10.1039/D2TB01150F
Silicone-containing thermoresponsive membranes to form an optical glucose biosensor
An optical glucose biosensor was fabricated by tailoring a thermoresponsive membrane to house an oxygen-sensitive, phosphorescence lifetime glucose sensing assay. Silicone microparticles enhanced oxygen permeability, yielding a biosensor with an sensitivity range of 100 to 300 mg dL−1.
J. Mater. Chem. B, 2022,10, 6118-6132
https://doi.org/10.1039/D2TB01192A
Thermo- and ion-responsive silk-elastin-like proteins and their multiscale mechanisms
Three effects govern SELP's thermo- and ion-responsiveness to external stimuli: (1) each chain's inverse temperature transition, (2) intrachain geometry restraints due to aggregation, and (3) intermolecular electrostatic interactions.
J. Mater. Chem. B, 2022,10, 6133-6142
https://doi.org/10.1039/D2TB01002J
Biofunctional peptide-click PEG-based hydrogels as 3D cell scaffolds for corneal epithelial regeneration
Poly(ethylene glycol) (PEG)-based hydrogels as highly promising 3D cell scaffolds have been widely implemented in tissue regeneration, yet the functionalized PEG hydrogel providing dynamic, cell-instructive microenvironments is difficult to obtain.
J. Mater. Chem. B, 2022,10, 5938-5945
https://doi.org/10.1039/D2TB00983H
A cell membrane repair protein-based nanoformulation with multiple actuators for scarless wound healing
A novel remote light-controlled nanoformulation based on cell membrane repair protein was developed to achieve scarless healing of diabetic wounds.
J. Mater. Chem. B, 2022,10, 5733-5742
https://doi.org/10.1039/D2TB00992G
Arginine-grafted porcine pericardium by copolymerization to improve the cytocompatibility, hemocompatibility and anti-calcification properties of bioprosthetic heart valve materials
The introduction of arginine improved the hemocompatibility and cytocompatibility of PP and reduced its calcification, offering a potential option for BHV fabrication in the future.
J. Mater. Chem. B, 2022,10, 5571-5581
https://doi.org/10.1039/D2TB00798C
PgC3Mg metal–organic cages functionalized hydrogels with enhanced bioactive and ROS scavenging capabilities for accelerated bone regeneration
PgC3Mg metal–organic cages functionalized GelMA hydrogel with enhanced bioactive and ROS scavenging capabilities. The multifunctional GelMA/PgC3Mg hydrogel can promote osteogenesis in vitro and in vivo.
J. Mater. Chem. B, 2022,10, 5375-5387
https://doi.org/10.1039/D2TB00907B
Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating
This study systematically verified that magnetic hyperthermia (MH) with intracellular heating can induce genuine immunogenic tumor cell death for effective antitumor therapy, while exogenous heating fails to elicit this effect.
J. Mater. Chem. B, 2022,10, 5364-5374
https://doi.org/10.1039/D2TB01004F
Superoxide dismutase-embedded metal–organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease
Inflammatory bowel disease (IBD) is characterized by chronic and spontaneous inflammation in the gastrointestinal tract, and has been associated with an improved level of reactive oxygen species (ROS).
J. Mater. Chem. B, 2022,10, 5174-5181
https://doi.org/10.1039/D2TB00896C
Fabrication of injectable hydrogels from an anticancer peptide for local therapeutic delivery and synergistic photothermal–chemotherapy
An injectable hydrogel with the potential for synergistic photothermal–chemotherapy was developed from an anticancer peptide.
J. Mater. Chem. B, 2022,10, 5165-5173
https://doi.org/10.1039/D2TB00917J
A cationic BODIPY photosensitizer decorated with quaternary ammonium for high-efficiency photodynamic inhibition of bacterial growth
A cationic BODIPY photosensitizer decorated with quaternary ammonium has been prepared that exhibits excellent photodynamic antibacterial effects.
J. Mater. Chem. B, 2022,10, 4967-4973
https://doi.org/10.1039/D2TB00778A
Cadherin-dependent adhesion modulated 3D cell-assembly
Cadherins are widely expressed in mammalian cells. By regulating the expression of different subtypes of cadherin and regulating the proportion of added cells, three-dimensional cell assemblies with special structures were assembled.
J. Mater. Chem. B, 2022,10, 4959-4966
https://doi.org/10.1039/D2TB01006B
Host–guest interaction-based supramolecular prodrug self-assemblies for GSH-consumption augmented chemotherapy
The chemotherapy is perplexed by the unsatisfied efficacy due to the GSH-induced detoxification. The SPSAs reported in this study could not only consume GSH but also reduce GSH biosynthesis pathway, paving a novel way to enhance therapeutic efficacy.
J. Mater. Chem. B, 2022,10, 4952-4958
https://doi.org/10.1039/D2TB00989G
Polythiophene as a near full pH photo-antimicrobial
Polythiophene (PT10), a cationic polymer, exhibited both broad-spectrum photo-antimicrobial activity (Gram positive, Gram negative, Fungal, and cyano-bacteria) and broad pH responsiveness (constant 1O2 generation at pH 2-13).
J. Mater. Chem. B, 2022,10, 4944-4951
https://doi.org/10.1039/D2TB00727D
Doxorubicin-encapsulated thermosensitive liposome-functionalized photothermal composite scaffolds for synergistic photothermal therapy and chemotherapy
Photothermal composite scaffolds of doxorubicin-encapsulated thermosensitive liposomes, gold nanorods, gelatin and polyglutamic acid have synergistic anticancer effects of PTT and chemotherapy to eliminate breast cancer cells.
J. Mater. Chem. B, 2022,10, 4771-4782
https://doi.org/10.1039/D2TB00993E
Au nanocluster-modulated macrophage polarization and synoviocyte apoptosis for enhanced rheumatoid arthritis treatment
Au25 nanoclusters as a self-therapeutic nanodrug significantly modulated macrophage polarization from M1 to M2 and could act as an inhibitor of thioredoxin reductase (TrxR), which induced ROS-mediated FLS apoptosis by breaking redox homeostasis.
J. Mater. Chem. B, 2022,10, 4789-4799
https://doi.org/10.1039/D2TB00869F
Construction of a copper nanocluster/MnO2 nanosheet-based fluorescent platform for butyrylcholinesterase activity detection and anti-Alzheimer's drug screening
This work sheds light on the construction of a copper nanocluster/MnO2 nanosheet based fluorescent platform for butyrylcholinesterase sensing and inhibitor screening.
J. Mater. Chem. B, 2022,10, 4783-4788
https://doi.org/10.1039/D2TB00318J
A rational design of a cascaded DNA circuit for nanoparticle assembly and its application in the discrimination of single-base changes
A rational design of a cascaded circuit is presented, effectively eliminating leakage, purification and reducing assembly time for application.
J. Mater. Chem. B, 2022,10, 4561-4567
https://doi.org/10.1039/D2TB00155A
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Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants
Long acting release of the water soluble nucleoside reverse transcriptase inhibitor emtricitabine (FTC) has been demonstrated in vitro through polymer formation using FTC as a monomer, and forming implants made of the drug containing polymer.
J. Mater. Chem. B, 2022,10, 4395-4404
https://doi.org/10.1039/D2TB00825D
Dual crosslinking hydrogels with tunable injectability and stability for bone repair
A triblock polypeptide is synthesized and dual crosslinking PTA hydrogels are constructed. The hydrogels exhibit good shear-thinning and self-healing properties, as well as exhibit better stability due to increased crosslinking density.
J. Mater. Chem. B, 2022,10, 4386-4394
https://doi.org/10.1039/D2TB00545J
Conjugating aldoxorubicin to supramolecular organic frameworks: polymeric prodrugs with enhanced therapeutic efficacy and safety
Supramolecular organic frameworks have been utilized to conjugate aldoxorubicin to give polymeric prodrugs, which achieves enhanced anti-tumour activity through the delivery of the frameworks.
J. Mater. Chem. B, 2022,10, 4163-4171
https://doi.org/10.1039/D2TB00678B
Influences of viscosity on the osteogenic and adipogenic differentiation of mesenchymal stem cells with controlled morphology
The influences of viscosities of culture media on osteogenic and adipogenic differentiation of mesenchymal stem cells are investigated by controlling cell morphology with micropatterned surfaces.
J. Mater. Chem. B, 2022,10, 3989-4001
https://doi.org/10.1039/D2TB00729K
An efficient photothermal–chemotherapy platform based on a polyacrylamide/phytic acid/polydopamine hydrogel
An effective platform for chemophotothermal therapy based on a polyacrylamide/phytic acid/polydopamine hydrogel was constructed and applied to tumor treatment with its highly efficient drug loading and photothermal heating properties.
J. Mater. Chem. B, 2022,10, 4012-4019
https://doi.org/10.1039/D2TB00677D
Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis
Pt-lipid coated probiotics have better resistance to the harsh environment of the gastrointestinal tract, improving the homeostasis of the intestinal epithelial barrier and offering considerable potential for the treatment of ulcerative colitis.
J. Mater. Chem. B, 2022,10, 4002-4011
https://doi.org/10.1039/D2TB00300G
Tumor-responsive nanomedicine based on Ce3+-modulated up-/downconversion dual-mode emission for NIR-II imaging-guided dynamic therapy
The lanthanide-doped nanoparticles with upconversion and NIR-II downconversion dual-mode emissions were coated with copper and manganese silicate nanospheres and modified with sodium alginate for NIR-II imaging and dynamic therapy.
J. Mater. Chem. B, 2022,10, 3824-3833
https://doi.org/10.1039/D2TB00626J
Versatile metal–organic frameworks as a catalyst and an indicator of nitric oxide
Versatile metal–organic frameworks were designed as a self-controlled catalyst for the denitrosylation of S-nitrosothiols and an indicator of nitric oxide in living cells.
J. Mater. Chem. B, 2022,10, 3817-3823
https://doi.org/10.1039/D2TB00480A
About this collection
This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2022 marked as HOT (selected by our Editors as especially significant based on reviewers’ recommendations and their own appraisal). Congratulations to all the authors whose articles are featured!