Issue 48, 2023

Catalytic dehydrative amide bond formation using aqueous ammonia: synthesis of primary amides utilizing diboronic acid anhydride catalysis

Abstract

Although aqueous ammonia is an inexpensive and readily available safe source of ammonia, there have been no successful studies on direct catalytic dehydrative amidations of carboxylic acids with aqueous ammonia. In this study, we report a catalytic methodology for the synthesis of primary amides through diboronic acid anhydride (DBAA)-catalyzed dehydrative condensation of carboxylic acids with aqueous ammonia as the amine substrate.

Graphical abstract: Catalytic dehydrative amide bond formation using aqueous ammonia: synthesis of primary amides utilizing diboronic acid anhydride catalysis

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2023
Accepted
20 May 2023
First published
26 May 2023

Chem. Commun., 2023,59, 7391-7394

Catalytic dehydrative amide bond formation using aqueous ammonia: synthesis of primary amides utilizing diboronic acid anhydride catalysis

N. Takahashi, H. Iwasawa, T. Kinashi, K. Makino and N. Shimada, Chem. Commun., 2023, 59, 7391 DOI: 10.1039/D3CC02071A

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