Issue 18, 2024

Skin-interfaced microfluidic biosensors for colorimetric measurements of the concentrations of ketones in sweat

Abstract

Ketones, such as beta-hydroxybutyrate (BHB), are important metabolites that can be used to monitor for conditions such as diabetic ketoacidosis (DKA) and ketosis. Compared to conventional approaches that rely on samples of urine or blood evaluated using laboratory techniques, processes for monitoring of ketones in sweat using on-body sensors offer significant advantages. Here, we report a class of soft, skin-interfaced microfluidic devices that can quantify the concentrations of BHB in sweat based on simple and low-cost colorimetric schemes. These devices combine microfluidic structures and enzymatic colorimetric BHB assays for selective and accurate analysis. Human trials demonstrate the broad applicability of this technology in practical scenarios, and they also establish quantitative correlations between the concentration of BHB in sweat and in blood. The results represent a convenient means for managing DKA and aspects of personal nutrition/wellness.

Graphical abstract: Skin-interfaced microfluidic biosensors for colorimetric measurements of the concentrations of ketones in sweat

Supplementary files

Article information

Article type
Paper
Submitted
10 Jul 2024
Accepted
14 Aug 2024
First published
28 Aug 2024
This article is Open Access
Creative Commons BY license

Lab Chip, 2024,24, 4288-4295

Skin-interfaced microfluidic biosensors for colorimetric measurements of the concentrations of ketones in sweat

Y. Wu, X. Li, K. E. Madsen, H. Zhang, S. Cho, R. Song, R. F. Nuxoll, Y. Xiong, J. Liu, J. Feng, T. Yang, K. Zhang, A. J. Aranyosi, D. E. Wright, R. Ghaffari, Y. Huang, R. G. Nuzzo and J. A. Rogers, Lab Chip, 2024, 24, 4288 DOI: 10.1039/D4LC00588K

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