Issue 51, 2024

Chemoselective oxidation of aromatic aldehydes to carboxylic acids: potassium tert-butoxide as an anomalous source of oxygen

Abstract

Chemoselective oxidation of aromatic and heteroaromatic aldehydes (>45 examples) to their corresponding carboxylic acids has been developed. Potassium tert-butoxide acts as an oxygen source during this transformation that delivers the corresponding acids without chromatographic purifications. The use of bench-top reagents, operational simplicity, and high level of chemo-selectivity with respect to oxidation of the least preferred aldehyde functionality, in the presence of more susceptible functional groups, are some of the highlights of this strategy.

Graphical abstract: Chemoselective oxidation of aromatic aldehydes to carboxylic acids: potassium tert-butoxide as an anomalous source of oxygen

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2024
Accepted
16 May 2024
First published
17 May 2024

Chem. Commun., 2024,60, 6544-6547

Chemoselective oxidation of aromatic aldehydes to carboxylic acids: potassium tert-butoxide as an anomalous source of oxygen

W. I. Lone, A. Rashid, B. A. Bhat and S. Rashid, Chem. Commun., 2024, 60, 6544 DOI: 10.1039/D4CC01639D

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