Issue 39, 2024

Nickel-catalyzed C(sp2)–C(sp3) coupling via photoactive electron donor–acceptor complexes

Abstract

We have developed a novel Ni-catalyzed reductive cross-coupling reaction of aryl bromides and alkyl iodides via a photoactive electron donor–acceptor (EDA) complex. This photo-induced process enables the efficient construction of C(sp2)–C(sp3) bonds in the absence of an external photocatalyst. Electronically and structurally diverse aryl bromides, as well as secondary and primary alkyl iodides could undergo this transformation smoothly. Natural product derivatives were employed successfully, and UV-vis spectroscopy was utilized to gain mechanistic insight.

Graphical abstract: Nickel-catalyzed C(sp2)–C(sp3) coupling via photoactive electron donor–acceptor complexes

Supplementary files

Article information

Article type
Communication
Submitted
16 Jan 2024
Accepted
05 Apr 2024
First published
19 Apr 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 5153-5156

Nickel-catalyzed C(sp2)–C(sp3) coupling via photoactive electron donor–acceptor complexes

S. Alsharif, C. Zhu, X. Liu, S. Lee, H. Yue and M. Rueping, Chem. Commun., 2024, 60, 5153 DOI: 10.1039/D4CC00217B

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