Issue 23, 2024

Silver(i)-catalyzed highly para-selective phosphonation of 2-aryloxazolines

Abstract

A silver-catalyzed phosphonation of 2-aryloxazolines has been accomplished. This protocol provides highly regioselective access to para-phosphonation products with good functional group tolerance and moderate to good yields via cross-dehydrogenation coupling. Mechanistic studies have shown that para-phosphonation products are obtained via a radical pathway. Furthermore, the directing oxazoline group in the para-phosphonation products is removable and can be converted to benzoic esters.

Graphical abstract: Silver(i)-catalyzed highly para-selective phosphonation of 2-aryloxazolines

Supplementary files

Article information

Article type
Communication
Submitted
26 Dec 2023
Accepted
08 Feb 2024
First published
26 Feb 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 3150-3153

Silver(I)-catalyzed highly para-selective phosphonation of 2-aryloxazolines

P. Cui and G. Wang, Chem. Commun., 2024, 60, 3150 DOI: 10.1039/D3CC06241D

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