Issue 69, 2023

Switchable reactivity of 2-benzoyl glycals towards stereoselective access of 1-3 and 1-1 S/O linked disaccharides

Abstract

We have developed a synthesis of 1-3 and 1-1 disaccharides from 2-benzoyl glycal and anomeric thiol and/or hydroxy sugar acceptors under mild conditions at room temperature. The regio and stereo-selectivity of the newly formed inter-glycosidic linkages are dependent on the nature of the glycal donor (D or L) and anomeric acceptor.

Graphical abstract: Switchable reactivity of 2-benzoyl glycals towards stereoselective access of 1-3 and 1-1 S/O linked disaccharides

Supplementary files

Article information

Article type
Communication
Submitted
15 Jun 2023
Accepted
31 Jul 2023
First published
31 Jul 2023

Chem. Commun., 2023,59, 10448-10451

Switchable reactivity of 2-benzoyl glycals towards stereoselective access of 1-3 and 1-1 S/O linked disaccharides

I. A. Zargar, B. Rasool, N. Sakander and D. Mukherjee, Chem. Commun., 2023, 59, 10448 DOI: 10.1039/D3CC02870D

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